MECHANISM OF COMPETITIVE INHIBITION OF p -AMINOBENZOIC ACID OXIDATION BY p -AMINOSALICYLIC ACID
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چکیده
منابع مشابه
Mechanism of competitive inhibition of p-aminobenzoic acid oxidation by p-aminosalicylic acid.
The proposed mechanism(s) associated with the inhibition of essential metabolic reactions by various compounds has received a great deal of attention in recent years, since antimetabolites have proved useful in several chemotherapeutic areas and in studying various metabolic reactions. The significance of p-aminobenzoic acid in microbial nutrition was first emphasized when Woods (1940) and Wood...
متن کاملINHIBITION OF ESCHERICHIA COLI BY p-AMINOBENZOIC ACID AND ITS REVERSAL BY p-HYDROXYBENZOIC ACID
p-Aminobenzoic acid (PABA) exerts three metabolic effects on E. coli: it acts as a normal vitamin at low concentrations, as a source of another vitamin, p-hydroxybenzoic acid (POB), at moderate concentrations, and as a growth inhibitor at high concentrations (150 to 1600 microg./ml.). The inhibition is competitively reversed by POB in 1/100 the concentration of PABA. The inhibition is also reve...
متن کاملInhibition by acetylsalicylic acid of rickettsial strains resistant to p-aminobenzoic acid.
Two p-aminobenzoic acid-resistant mutants of the Madrid E strain of Rickettsia prowazekii, pr and prr have been described in previous publications (Weiss et al., 1957; 1959). It has been shown that certain properties, such as antigenic specificity, infectivity, and virulence for the chick embryo and cotton rat, have not changed in these strains. However, when the study was extended to susceptib...
متن کاملSeparation of p-Aminobenzoic Acid Derivatives
According to the literature, p-aminobenzoic acid (PAB) is excreted in the urine mostly as the free acid and its N-acetyl derivative; the remaining part is eliminated conjugated with glucuronic acid and as p-aminohippuric acid (PAH) (Ellinger & Hensel, 1914'; Hensel, 1914; Cohen & McGilvery, 1946; Salassa, Bollman & Dry, 1948). There is no agreement concerning the formation of PAH. Thus, Beyer, ...
متن کاملEffect of structurally related compounds on the oxidation of p-aminobenzoic acid by Pseudomonas fluorescens.
The realization that p-aminobenzoic acid is essential as a growth factor has stimulated extensive research in the field of antagonists of this essential metabolite. Woods (1940) and Woods and Fildes (1940) reported that yeast contained a substance, identified as p-aminobenzoic acid, that could protect it against the growth inhibiting action of sulfanilamide. Youmans et al. (1947) reported the t...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1960
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.80.2.225-231.1960